Please note that this comment thread is now closed to further posts. A further limitation is that this assay included antigens for the two alphacoronaviruses (229E, NL63) rather than the more closely related betacoronaviruses (OC43 and … Bill & Melinda Gates Foundation. Attal M, Richardson PG, Rajkumar SV, et al. 2017 May 13;389(10082):1907-1918. doi: 10.1016/S0140-6736(17)30505-6. 2020;396:267-276. 2020 May;20(5):565-574. doi: 10.1016/S1473-3099(20)30196-1. These were the questions addressed by the SEMIRA study, a large European trial led by Charité – Universitätsmedizin Berlin. Lancet. This multicentre study reports on ECMO network organisation and outcomes during the COVID-19 pandemic in Greater Paris, one of the first regions in France to be severely affected, and where ECMO has been used to treat refractory acute respiratory distress syndrome (ARDS) related to COVID-19. The report in The Lancet queried whether early discontinuation of glucocorticoids could prevent characteristic side effects and asked how the drugs could be discontinued without sparking glucocorticoid withdrawal syndrome. Articles. Isatuximab plus pomalidomide and low-dose dexamethasone versus pomalidomide and low-dose dexamethasone in patients with relapsed and refractory multiple myeloma (ICARIA-MM): a randomised, multicentre, open-label, phase 3 study. A new study raised questions about whether that is necessary. International Journal of Public Health, 63 (Supplement 1). 2021;397:258-259. Continuing versus tapering glucocorticoids after achievement of low disease activity or remission in rheumatoid arthritis (SEMIRA): a double-blind, multicentre, randomised controlled trial . PubMed July 2020; BURMESTER GR, Buttgereit F, Bernasconi C, Alvaro-Gracia JM, et al Continuing versus tapering glucocorticoids after achievement of low disease activity or remission in rheumatoid arthritis (SEMIRA): a double-blind, multicentre, randomised controlled trial. These were the questions addressed by the SEMIRA study, a large European trial led by Charité - Universitätsmedizin Berlin. De Angelis R, Sant M, Coleman MP, Francisci S, Baili P, Pierannunzio D, et al. The Lancet | July 24, 2020. Is the long-term use of glucocorticoids essential in people with chronic inflammatory diseases such as rheumatoid arthritis, or can early discontinuation prevent characteristic side effects? Their long-term use, however, is associated with severe side effects, including cardiovascular disorders, osteoporosis and infections. PLoS One, 13 (9) Taylor, Celia A., Lilford, Richard, Wroe, Emily, Griffiths, Frances, Ngechu, Ruth, 2018. We obtained samples of blood, urine, posterior oropharyngeal saliva, and rectal swabs. Elimination In Rheumatoid Arthritis (SEMIRA) study, a trial including more than 250 participants recruited from close to 40 trial centers in six different countries. 2020 07 25; 396(10246):267-276. OpenUrl CrossRef PubMed. Serial viral load was ascertained by reverse transcriptase quantitative PCR (RT-qPCR). According to the trial’s findings, continuous glucocorticoid regimens were better at controlling disease activity. Evidence from randomised controlled trials to guide tapering of oral glucocorticoids is scarce. pp. 37. (2018) Burden of obesity in the Eastern Mediterranean region : findings from the Global Burden of Disease 2015 study. 396 , 10246 , S. 267-276 10 S. How can these drugs be discontinued without giving rise to glucocorticoid withdrawal syndrome? Further, as the [SEMIRA study] demonstrated, low-dose glucocorticoid therapy may be safe to use, at least in the short-term. Lancet Infect Dis. Reference: Orange DE, Yao V, Sawicka K, Fak J, Frank MO, Parveen S, Blachere NE, Hale C, Zhang F, Raychaudhuri S, Troyanskaya OG, Darnell RB. Here is my response to the recent article published in the Lancet Journal of Public Health. Semira Manaseki-Holland manages the Master’s in Public Health (Global) at the University of Birmingham. Articles . Aggregated study-level data, stratified by baseline 25(OH)D concentration and age, were obtained from study authors. CiteScore: 37.4 ℹ CiteScore: 2020: 37.4 CiteScore measures the average citations received per peer-reviewed document published in this title. 165-176. Results from this trial have been published in The Lancet. 15 Briefly, this trial was a community-based, double-blind, randomized, placebo-controlled parallel trial that was conducted between November 2007 and June 2009 in 5 inner-city districts of Kabul, Afghanistan. Lancet.2020;396(10246):267-76 (pubmed link) ... FAST Study in Gout Scouting report: available 3/15 Reference: Mackenzie et al. Volume 396, Issue 10246, 25–31 July 2020, Pages 267-276. Results from this trial have been published in The Lancet. The predictive validity of the Living Goods selection tools for community health workers in Kenya : cohort study. * Glucocorticoids, such as cortisone, are highly effective in controlling inflammatory diseases. Lancet. One study (NCT02573012) compared RA disease activity among patients randomised to continue versus stop versus taper off long-term oral GCs, but was limited to patients maintained on tocilizumab. Continuing versus tapering glucocorticoids after achievement of low disease activity or remission in rheumatoid arthritis (SEMIRA): a double-blind, multicentre, randomised controlled trial SEMIRA collaborators, 25.07.2020 , in : LANCET. SEMIRA Study in RA Scouting report: available 3/15 Reference: Burmester et al. Do low-carb diets really lead to early death? Yen-Fu studied pharmacy at the National Taiwan University before coming to the UK for postgraduate training in biopharmacy at King's College London and then public health and health services research at the University of Nottingham. GBD 2015 Eastern Mediterranean Region Obesity Collaborators (Including: Mokdad, Ali H. and Gill, Paramjit). Abstract. The Lancet. We developed a dedicated organisation to pool resources and regulate interventions. He and his Deputy Head of Department, Prof. Dr. Frank Buttgereit, form part of the team responsible for conducting the Steroid Elimination In Rheumatoid Arthritis (SEMIRA) study… A more detailed description of the trial methods, including the trial profile, has been published elsewhere. Skip to main content Advanced Search ... Methods: We did a cohort study at two hospitals in Hong Kong. 38. This study aims to take advantage of this complexity to develop more accurate serological diagnostics. BACKGROUND . Methods: The study sample comprised 111 confirmed hospitalized patients with SARS-CoV-2 and 70 healthy volunteer individuals. The Lancet. Patients with inflammatory diseases, such as rheumatoid arthritis, often receive glucocorticoids, but long-term use can produce adverse effects. Continuing versus tapering glucocorticoids after achievement of low disease activity or remission in rheumatoid arthritis (SEMIRA): a double-blind, multicentre, randomised controlled trial. The comments that have been posted on this preprint will remain available on this page. Prospective, Multicentre, Placebo-controlled, Double-blind Interventional Study to Compare the Efficacy of Maintenance Treatment With Tocilizumab With or Without Glucocorticoid Discontinuation in Rheumatoid Arthritis Patients: Actual Study Start Date : March 29, 2016: Actual Primary Completion Date : February 9, 2018: Actual Study Completion Date : NEXT . * Glucocorticoids, such as cortisone, are highly effective in controlling inflammatory diseases. Study Design. Lct. Author links open overlay panel Prof Gerd R Burmester MD a † Prof Frank Buttgereit MD a † Corrado Bernasconi MD b … Lancet.2020;396(10264):1745-57 (pubmed link) ACR 2020 Gout Guidelines Scouting report: available 3/15 Reference: Fitzgerald et al. CiteScore values are based on citation counts in a range of four years (e.g. Patients with cancer appear more vulnerable to SARS-COV-2: a multi-center study during the COVID-19 outbreak. Estimates and 25-year trends of the global burden of disease attributable to ambient air pollution: an analysis of data from the Global Burden of Diseases Study 2015 Lancet . AC&R.2020;72(6):744-60 (pubmed link) … We included patients with laboratory-confirmed COVID-19. Lancet. Lancet 2020; 395: 1907 – 18. ↵ Dai M, Liu D, Liu M, Zhou F, Li G, Chen Z, et al. Cancer survival in Europe 1999–2007 by country and age: results of EUROCARE–5-a population-based study. Clinical impact of COVID-19 on patients with cancer (CCC19): a cohort study. Their long-term use, however, is associated with severe side effects, including cardiovascular disorders, osteoporosis and infections. -A new study (see below) using longitudinal genomics to provide new insights into the pathogenesis of RA flares and describing a new type of cell: PRIME cells. Volume 396, Issue 10246, 25–31 July 2020, Pages 267-276. METHODS: The Steroid EliMination In Rheumatoid Arthritis (SEMIRA) trial was a double-blind, multicentre, two parallel-arm, randomised controlled trial done at 39 centres from six countries (France, Germany, Italy, Russia, Serbia, and Tunisia). Formative evaluation of a training intervention for community health workers in South Africa : a before and after study. Methods: A multiplex serological assay was developed to measure IgG and IgM antibody responses to seven SARS-CoV-2 spike or nucleoprotein antigens, two antigens for the nucleoproteins of the 229E and NL63 seasonal coronaviruses, and three non-coronavirus antigens. OpenUrl Abstract / FREE Full Text. In this study, we investigated the surge of IL-6 level and its association with the critical health factors in these patients. Journal Summary. The Lancet Infectious Diseases has removed the preprint, replacing it with: We have removed this preprint due to concerns about the description of the research in this paper. This double-blind, multicentre, two parallel-arm, randomised controlled trial—the Steroid EliMination In Rheumatoid Arthritis (SEMIRA) trial—was conducted to investigate a scheme for tapering oral glucocorticoids vs continuing low-dose oral glucocorticoids in patients suffering from rheumatoid arthritis. Cancer Discov 2020; 10: 783 – 91. A limitation of this study is the absence of samples from individuals collected more than 39 days after symptom onset, and the absence of samples from individuals with RT-qPCR-confirmed asymptomatic SARS-CoV-2 infection. As Senior Clinical Lecturer in Public Health, Semira teaches students at undergraduate and postgraduate level, including supervision of a number of PhDs. This has led us to initiate an investigation into this study. The last ( NCT02997605 ) was the only study to compare the efficacy of two different GC tapering regimens in allowing patients with established RA to discontinue long-term oral GCs. 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